Selected Publications

Human subtelomeric DNA methylation: regulation and roles in telomere function. Toubiana, S. and Selig S. Current Opinion in Genetics and Development (2020) 60:9-16.

Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction. Toubiana, S., Gagliardi, M., Papa, M., Manco, R., Tzukerman, M., Matarazzo, M.R. and Selig, S. eLife (2019) 18;8. pii: e47859. doi: 10.7554/eLife. 47859.

DNA:RNA hybrids at telomeres – when it’s better to be out of the (R) loop. Toubiana, S. and Selig, S. The FEBS Journal, (2018) 285:2552-2566.

Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric Instability and Facial Anomalies (ICF) syndrome. Toubiana, S., Velasco, G., Chityat, A., Kaindl, A.M., Hershtig, N., Tzur-Gilat, A., Francastel, C. and Selig, S.  Human Molecular Genetics (2018) 27:3568-3581.

Non-random length distribution of individual telomeres in Immunodeficiency, Centromeric Instability and Facial anomalies syndrome, type I. Sagie, S., Edni, O., Weinberg, J., Toubiana, S., Kozlovski, T., Frostig, T., Katzin, N., Bar-Am, I. and Selig, S. Human Molecular Genetics (2017) 26:4244-4256.

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids. Sagie, S., Toubiana, S., Hartono, S., Katzir, H., Tzur-Gilat, A., Havazelet, S, Francastel, C., Velasco, G., Chedin, F. and Selig, S. Nature Communications (2017) 8:14015.

Mutations In Stn1 cause Coats Plus syndrome and are associated with genomic and telomere defects.Simon, A.J., Lev, A., Zhang, Y., Weiss, B., Rylova, A., Eyal, E., Kol, N., Barel, O., Cesarkas, K., Soudack, M., Greenberg-Kushnir, N., Rhodes, M., Wiest, D.L., Schiby, G., Barshack, I., Katz, S., Pras, E., Poran, H., Reznik-Wolf, H., Ribakovsky, E., Simon, C., Hazou, W., Sidi, Y., Lahad, A., Katzir, H., Sagie, S., Glousker, G., Amariglio, N., Tzfati, Y., Selig, S., Rechavi, G.& Somech, R.  Journal Experimental Medicine (2016) 213, 1429-1440. http://10.1084/jem.20151618

Induced pluripotent stem cells as a model for telomeric abnormalities in ICF type I syndrome.  Sagie, S., Ellran, E., Katzir, H., Shaked, R., Yehezkel, S., Laevsky, I., Ghanayim, A., Geiger, D., Tzukerman, M. and Selig, S. Human Molecular Genetics (2014) 23, 3629-3640.

Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts. Yehezkel, S., Shaked, R., Sagie, S., Berkovitz, R., Shachar-Bener, H., Segev, Y. and Selig, S. Frontiers Oncology (2013) 3:35. http://10.3389/fonc.2013.00035

Digital image analysis of cells stained with the senescence-associated b-galactosidase assay. Shlush, L.I. and Selig S. Methods in Molecular Biology (2013) 1048, 11-18.

Quantitative Digital In Situ Senescence-Associated beta-Galactosidase Assay. Shlush, L.I., Itzkovitz, S., Cohen, A., Rutenberg, A., Berkovitz, R., Yehezkel, S., Shahar, H., Selig, S.* and Skorecki, K. BMC Cell Biology (2011) 12, 16. http://10.1186/1471-2121-12-16

Telomere elongation followed by telomere length reduction, in leukocytes from divers exposed to intense oxidative stress – Implications for tissue and organismal aging. Shlush, L.I., Skorecki, K.L., Itzkovitz, S., Yehezkel, S., Segev, Y., Shachar, H., Berkovitz, R., Adir, Y., Vulto, I., Lansdorp, P.M., Selig, S.  Mechanisms Ageing Development (2011) 132, 123-130.

Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives. Yehezkel, S., Rebibo-Sabbah, A., Segev, Y., Tzukerman, M., Shaked, R., Huber, I., Gepstein, L., Skorecki, K. and Selig, S. Epigenetics (2011) 6, 63-75.

Allelic inactivation of rDNA loci. Schlesinger, S., Selig, S., Bergman, Y. and Cedar, H.  Genes and Development (2009) 23, 2437-2447. http://10.1101/gad.544509

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Yehezkel, S., Segev, Y., Viegas- Péquignot, E., Skorecki, K. and Selig, S. Human Molecular Genetics (2008) 17, 2776-2789.

Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Ding, D., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., Pourvali, R., Poon, S., Vulto, I., Chavez, E, Tam, P.P.L., Nagy, A and Lansdorp, P.  Cell (2004) 117, 873-886.

Sister chromatid separation at human telomeric regions.Yalon, M., Gal, S., Segev, Y., Selig, S, Skorecki, K.L.  Journal Cell Science (2004) 117, 1961-1970. doi: 10.1242/jcs.01032

Replication and/or separation of some human telomeres is delayed beyond S- phase in pre-senescent cells. Ofir, R., Yalon-Hacohen, M., Segev, Y., Schultz, A., Skorecki, K.L. and Selig, S. Chromosoma (2002) 111, 147-155.

Position effect of human telomeric repeats on replication timing. Ofir, R., Wong, A.C.C., McDermid, H.E. and Skorecki, K. and Selig, S.  Proc. Natl. Acad. Sci. USA (1999) 96, 11434-11439.